biotinylated anti mic 1 ab Search Results


growth differentiation factor 15 gdf15  (Bioss)
93
Bioss growth differentiation factor 15 gdf15
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Growth Differentiation Factor 15 Gdf15, supplied by Bioss, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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goat anti mic 1 gdf  (R&D Systems)
92
R&D Systems goat anti mic 1 gdf
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Goat Anti Mic 1 Gdf, supplied by R&D Systems, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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biotinylated anti mic 1 ab  (R&D Systems)
92
R&D Systems biotinylated anti mic 1 ab
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Biotinylated Anti Mic 1 Ab, supplied by R&D Systems, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti-goat antibody  (Jackson Immuno)
90
Jackson Immuno anti-goat antibody
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Anti Goat Antibody, supplied by Jackson Immuno, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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biotinylated donkey anti sheep igg  (Jackson Immuno)
94
Jackson Immuno biotinylated donkey anti sheep igg
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Biotinylated Donkey Anti Sheep Igg, supplied by Jackson Immuno, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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biotinylated goat anti mouse igg  (Jackson Immuno)
96
Jackson Immuno biotinylated goat anti mouse igg
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Biotinylated Goat Anti Mouse Igg, supplied by Jackson Immuno, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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streptavidin hrp conjugate  (Jackson Immuno)
96
Jackson Immuno streptavidin hrp conjugate
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Streptavidin Hrp Conjugate, supplied by Jackson Immuno, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bsa  (Boehringer Mannheim)
90
Boehringer Mannheim bsa
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Bsa, supplied by Boehringer Mannheim, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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horseradish peroxidase-conjugated streptavidin  (Genzyme)
90
Genzyme horseradish peroxidase-conjugated streptavidin
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Horseradish Peroxidase Conjugated Streptavidin, supplied by Genzyme, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse cell signaling technology  (Cell Signaling Technology Inc)
99
Cell Signaling Technology Inc mouse cell signaling technology
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Mouse Cell Signaling Technology, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit cell signaling technology  (Cell Signaling Technology Inc)
99
Cell Signaling Technology Inc rabbit cell signaling technology
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Rabbit Cell Signaling Technology, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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donkey anti goat af488 jackson immunoresearch  (Jackson Immuno)
96
Jackson Immuno donkey anti goat af488 jackson immunoresearch
Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and <t>growth</t> <t>differentiation</t> <t>factor-15</t> <t>(GDF15)</t> expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.
Donkey Anti Goat Af488 Jackson Immunoresearch, supplied by Jackson Immuno, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and growth differentiation factor-15 (GDF15) expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.

Journal: The American Journal of Pathology

Article Title: Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice with Chronic Renal Disease

doi: 10.1016/j.ajpath.2014.11.026

Figure Lengend Snippet: Cathepsin S inhibitor RO5444101 decreases plaque size, macrophage accumulation, and growth differentiation factor-15 (GDF15) expression in the atherosclerotic arteries of Apoe−/− mice with chronic renal disease (CRD). A and D: Quantification of atherosclerotic plaque size at the lesser curvature of the aortic arch using hematoxylin and eosin (H&E) staining. B and E: Mac3 staining in the aortic arch (B) shows macrophage accumulation on representative images; quantitative analysis of Mac3 staining (E). C and F: Immunohistochemical staining for a proinflammatory cytokine, GDF15, in the aortic arch (C) and its quantification (F). Data represent means ± SD. ∗P < 0.05, ∗∗∗P < 0.001.

Article Snippet: Immunohistochemical analysis for macrophages (anti-mouse mac3; BD Biosciences, San Jose, CA), cathepsin S (anti-mouse cathepsin S; Santa Cruz Biotechnology, Santa Cruz, CA), osteocalcin (goat anti-mouse polyclonal antibody; Serotech, Dusseldorf, Germany), and growth differentiation factor-15 (GDF15) (rabbit anti–Gdf-15 polyclonal antibody; Bioss Antibodies, Woburn, MA) was performed using the avidin-biotin peroxidase method.

Techniques: Expressing, Staining, Immunohistochemical staining

Cathepsin S (CatS)–specific inhibition by RO5444101 attenuates interferon γ (IFN-γ)–induced expression of growth differentiation factor-15 (GDF15) and monocyte chemotactic protein-1 (MCP-1)/CCL2 in human and mouse macrophages. Cultured human primary macrophages (MΦ) differentiated from peripheral blood monocytes and mouse macrophage-like RAW264.7 cells were pretreated with cathepsin S inhibitor RO5444101 and then were incubated with IFN-γ. RO5444101 or siRNA against cathepsin S reduced IFN-γ–induced GDF15 (A) and MCP-1/CCL2 (B) expression in both human and mouse macrophages. N = 4 for all experiments. Data represent means ± SD. ∗P < 0.05 between comparisons. Ctrl, control; hIFN-γ, human IFN-γ; mIFN-γ, mouse IFN-γ.

Journal: The American Journal of Pathology

Article Title: Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice with Chronic Renal Disease

doi: 10.1016/j.ajpath.2014.11.026

Figure Lengend Snippet: Cathepsin S (CatS)–specific inhibition by RO5444101 attenuates interferon γ (IFN-γ)–induced expression of growth differentiation factor-15 (GDF15) and monocyte chemotactic protein-1 (MCP-1)/CCL2 in human and mouse macrophages. Cultured human primary macrophages (MΦ) differentiated from peripheral blood monocytes and mouse macrophage-like RAW264.7 cells were pretreated with cathepsin S inhibitor RO5444101 and then were incubated with IFN-γ. RO5444101 or siRNA against cathepsin S reduced IFN-γ–induced GDF15 (A) and MCP-1/CCL2 (B) expression in both human and mouse macrophages. N = 4 for all experiments. Data represent means ± SD. ∗P < 0.05 between comparisons. Ctrl, control; hIFN-γ, human IFN-γ; mIFN-γ, mouse IFN-γ.

Article Snippet: Immunohistochemical analysis for macrophages (anti-mouse mac3; BD Biosciences, San Jose, CA), cathepsin S (anti-mouse cathepsin S; Santa Cruz Biotechnology, Santa Cruz, CA), osteocalcin (goat anti-mouse polyclonal antibody; Serotech, Dusseldorf, Germany), and growth differentiation factor-15 (GDF15) (rabbit anti–Gdf-15 polyclonal antibody; Bioss Antibodies, Woburn, MA) was performed using the avidin-biotin peroxidase method.

Techniques: Inhibition, Expressing, Cell Culture, Incubation

Cathepsin S inhibition in atherosclerotic plaques in chronic renal disease. Inhibition of cathepsin S may reduce lesion size via decreasing growth differentiation factor-15 (GDF15), a modulator of macrophage chemotaxis. Cathepsin S inhibition also may decrease osteogenic stimuli, such as osteopontin and osteocalcin, by suppressing elastin degradation. CCR2, C-C chemokine receptor type 2.

Journal: The American Journal of Pathology

Article Title: Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice with Chronic Renal Disease

doi: 10.1016/j.ajpath.2014.11.026

Figure Lengend Snippet: Cathepsin S inhibition in atherosclerotic plaques in chronic renal disease. Inhibition of cathepsin S may reduce lesion size via decreasing growth differentiation factor-15 (GDF15), a modulator of macrophage chemotaxis. Cathepsin S inhibition also may decrease osteogenic stimuli, such as osteopontin and osteocalcin, by suppressing elastin degradation. CCR2, C-C chemokine receptor type 2.

Article Snippet: Immunohistochemical analysis for macrophages (anti-mouse mac3; BD Biosciences, San Jose, CA), cathepsin S (anti-mouse cathepsin S; Santa Cruz Biotechnology, Santa Cruz, CA), osteocalcin (goat anti-mouse polyclonal antibody; Serotech, Dusseldorf, Germany), and growth differentiation factor-15 (GDF15) (rabbit anti–Gdf-15 polyclonal antibody; Bioss Antibodies, Woburn, MA) was performed using the avidin-biotin peroxidase method.

Techniques: Inhibition, Chemotaxis Assay